Link: https://www.ncbi.nlm.nih.gov/books/NBK559112/
Description: Web ResultAug 17, 2023 · Valproic acid (VPA) ia as a highly prevalent medication with multifaceted therapeutic applications in various neurological and psychiatric disorders. The therapeutic uses of VPA include epilepsy treatment across different seizure types, bipolar disorder management, and migraine prophylaxis.
DA: 3 PA: 63 MOZ Rank: 89
Link: https://go.drugbank.com/drugs/DB00313
Description: Web ResultOral, mouse: 1098 mg/kg. Oral, rat: 670 mg/kg. Symptoms of overdose include somnolence, heart block, deep coma, and hypernatremia. Fatalities have been reported, however patients have recovered from valproate serum concentrations as high as 2120 mcg/mL. The unbound fraction may be removed by hemodialysis.
DA: 71 PA: 94 MOZ Rank: 95
Link: https://www.uptodate.com/contents/antiseizure-medications-mechanism-of-action-pharmacology-and-adverse-effects
Description: Web ResultJan 26, 2024 · The pharmacology of antiseizure medications is reviewed here. The use of antiseizure medications in a treatment plan for patients with seizures is discussed separately. Risks of antiseizure medications in pregnancy are also discussed separately.
DA: 21 PA: 66 MOZ Rank: 91
Link: https://en.wikipedia.org/wiki/Valproate
Description: Web ResultValproate ( valproic acid, VPA, sodium valproate, and valproate semisodium forms) are medications primarily used to treat epilepsy and bipolar disorder and prevent migraine headaches. [6] They are useful for the prevention of seizures in those with absence seizures, partial seizures, and generalized seizures. [6]
DA: 39 PA: 98 MOZ Rank: 100
Link: https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3696515/
Description: Web ResultValproic acid (VPA) is a branched short-chain fatty acid derived from naturally occurring valeric acid. VPA is used primarily in the treatment of epilepsy and seizures, but is also used in migraine, bipolar, mood, anxiety, and …
DA: 80 PA: 74 MOZ Rank: 80
Link: https://www.ncbi.nlm.nih.gov/books/NBK559112/figure/article-30956.image.f1/
Description: Web ResultShow details. Mechanism of Action of Valproic Acid. The figure illustrates the metabolic pathway of GABA synthesis and its metabolism involving α-ketoglutarate dehydrogenase, GABA transaminase, and succinate dehydrogenase. Valproic acid effectively inhibits the activity of the 2 catabolic enzymes involved in GABA …
DA: 60 PA: 70 MOZ Rank: 89
Link: http://www.druglib.com/druginfo/depakote/description_pharmacology/
Description: Web ResultDESCRIPTION. Divalproex sodium is a stable co-ordination compound comprised of sodium valproate and valproic acid in a 1:1 molar relationship and formed during the partial neutralization of valproic acid with 0.5 equivalent of sodium hydroxide. Chemically it is designated as sodium hydrogen bis (2-propylpentanoate).
DA: 100 PA: 15 MOZ Rank: 29
Link: https://reference.medscape.com/drug/depakote-divalproex-sodium-999832
Description: Web ResultDepakote initial dose: 750 mg/day PO in divided doses. Depakote ER initial dose: 25 mg/kg PO once daily Increase as rapidly as possible to achieve the lowest therapeutic dose that provides...
DA: 22 PA: 57 MOZ Rank: 62
Link: http://robholland.com/Nursing/Drug_Guide/data/monographframes/V004.html
Description: Web ResultAvailability. 250 mg capsules; 125 mg sprinkle capsules; 125 mg, 250 mg, 500 mg delayed-release tablets; 500 mg sustained-release tablets; 250 mg/5 mL syrup; 100 mg/mL injection. Actions. Anticonvulsant unrelated chemically to other drugs used to treat seizure disorders.
DA: 66 PA: 21 MOZ Rank: 68
Link: https://pubmed.ncbi.nlm.nih.gov/10812195/
Description: Web ResultPMID: 10812195. DOI: 10.1016/s0197-0186 (00)00013-9. Abstract. Valproate, one of the major antiepileptic drugs used today, has besides its wide use in both generalized and partial epilepsies, several new approved indications including the treatment of bipolar disorders, neuropathic pain, and as a migraine prophylaxis.
DA: 21 PA: 36 MOZ Rank: 12