Link: https://depakoteinfo.com/
Description: WebDepakote is commonly prescribed for the treatment of epilepsy, bipolar disorder, and migraines. Depakote works by increasing the levels of a chemical called gamma-aminobutyric acid (GABA) in the brain. GABA is a neurotransmitter that helps to calm down excessive electrical activity in the brain.
DA: 49 PA: 70 MOZ Rank: 74
Link: https://www.ncbi.nlm.nih.gov/books/NBK559112/
Description: WebAug 17, 2023 · Therapeutic ranges of VPA: The therapeutic range for total valproate in epilepsy is 50 to 100 mcg/mL, and in mania, it is 50 to 125 mcg/mL. To achieve the maximum concentration within the body, VPA generally takes around 14 days.
DA: 58 PA: 99 MOZ Rank: 91
Link: https://emedicine.medscape.com/article/2090462-overview
Description: WebNov 20, 2019 · The therapeutic range for valproic acid is 50-100 mcg/mL. The toxic level is >100 mcg/mL. [ 1] Next: Interpretation. Valproic acid is an 8-carbon 2-chain fatty acid that is metabolized by...
DA: 36 PA: 73 MOZ Rank: 62
Link: https://reference.medscape.com/drug/depakote-divalproex-sodium-999832
Description: WebDepakote initial dose: 750 mg/day PO in divided doses. Depakote ER initial dose: 25 mg/kg PO once daily Increase as rapidly as possible to achieve the lowest therapeutic dose that...
DA: 35 PA: 59 MOZ Rank: 77
Link: https://www.drugs.com/dosage/depakote.html
Description: WebFeb 24, 2023 · Depakote tablets are administered orally. The recommended initial dose is 750 mg daily in divided doses. The dose should be increased as rapidly as possible to achieve the lowest therapeutic dose which produces the desired clinical effect or the desired range of plasma concentrations.
DA: 87 PA: 46 MOZ Rank: 7
Link: https://www.drugs.com/dosage/divalproex-sodium.html
Description: WebFeb 23, 2024 · Plasma levels should be checked if satisfactory response has not been achieved (usual accepted therapeutic range 50 to 100 mcg/mL) Maximum dose: 60 mg/kg/day. SIMPLE AND COMPLEX ABSENCE SEIZURES: Initial Therapy: 15 mg/kg/day orally (see below for frequency)
DA: 32 PA: 82 MOZ Rank: 8
Link: https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4100435/
Description: WebThough it does not have a narrow therapeutic range as in the case of lithium, accurate estimation of its trough level is essential as any value below the lower limit of the therapeutic range is not effective and above it may result in adverse effects. [ 3] . Trough levels are more accurate when measured just before the next dose.
DA: 24 PA: 9 MOZ Rank: 24
Link: https://www.accessdata.fda.gov/drugsatfda_docs/label/2021/018723s064lbl.pdf
Description: WebINDICATIONS AND USAGE . Depakote is an anti-epileptic drug indicated for: . Treatment of manic episodes associated with bipolar disorder (1.1) Monotherapy and adjunctive therapy of...
DA: 4 PA: 63 MOZ Rank: 95
Link: https://www.mayoclinic.org/drugs-supplements/divalproex-sodium-oral-route/proper-use/drg-20072886?p=1
Description: WebApr 1, 2024 · Divalproex Sodium (Oral Route) Description and Brand Names. Drug information provided by: Merative, Micromedex ®. US Brand Name. Depakote DR. Depakote ER. Depakote Sprinkles. Canadian Brand Name. Alti-Valproic. Descriptions. Divalproex sodium is used to treat certain types of seizures (epilepsy).
DA: 4 PA: 57 MOZ Rank: 4
Link: https://reference.medscape.com/drug/valproic-acid-343024
Description: WebIndicated for prophylaxis of migraine headaches; there is no evidence of use for acute treatment. Stavzor: 250 mg PO q12hr; adjust dose based on clinical response, not to exceed 1000 mg/day. Depakote ER: 500 mg PO qDay for 7 days; based on patient response, may increase and adjust dose to 500-1000 mg/day.
DA: 93 PA: 37 MOZ Rank: 24
Link: https://medlineplus.gov/druginfo/meds/a682412.html
Description: WebValproic acid is used alone or with other medications to treat certain types of seizures. Valproic acid is also used to treat mania (episodes of frenzied, abnormally excited mood) in people with bipolar disorder (manic-depressive disorder; a disease that causes episodes of depression, episodes of mania, and other abnormal moods).
DA: 26 PA: 32 MOZ Rank: 27
Link: https://www.healthline.com/health/bipolar-disorder/valproic-acid-levels-for-bipolar
Description: WebOct 16, 2023 · Therapeutic monitoring: Observing valproic acid levels helps healthcare professionals ensure the drug is within the therapeutic range, which means it’s at a concentration that effectively...
DA: 3 PA: 60 MOZ Rank: 52
Link: https://alabamaclinics.com/services/labs/depakote-level/
Description: WebThe reference ranges for valproic acid are as follows: The therapeutic range for valproic acid (total) is 50-125 µg/mL. The toxic level is greater than 150 µg/mL. The therapeutic range for valproic acid (free) is 6-22 µg/mL.
DA: 14 PA: 24 MOZ Rank: 71
Link: https://www.healthline.com/health/drugs/depakote-dosage
Description: WebFeb 23, 2022 · Drug Images. Introduction. If you have certain types of seizures, migraine, or mood disorders, your doctor might suggest Depakote or Depakote ER as a treatment option. Depakote is a...
DA: 96 PA: 18 MOZ Rank: 37
Link: https://www.healthline.com/health/drugs/depakote
Description: WebApr 19, 2023 · Drug Images. What is Depakote? If you have bipolar disorder, epilepsy, or migraine, your doctor might suggest Depakote as a treatment option for you. It’s a prescription drug used to: treat...
DA: 87 PA: 35 MOZ Rank: 29
Link: https://accesspharmacy.mhmedical.com/content.aspx?sectionid=40843099&bookid=510
Description: WebThe generally accepted therapeutic range for total valproic acid steady-state concentrations is 50–100 μg/mL, although some clinicians suggest drug concentrations as high as 175 μg/mL with appropriate monitoring of serum concentrations and possible adverse effects.
DA: 26 PA: 40 MOZ Rank: 51
Link: https://www.drugs.com/depakote.html
Description: WebAug 23, 2023 · Medically reviewed by Sophia Entringer, PharmD. Last updated on Aug 23, 2023. Uses. Warnings. Dosage. What to avoid. Side effects. Interactions. What is Depakote? Depakote affects chemicals in the body that may be involved in causing seizures. Depakote is used to treat various types of seizure disorders. therapeutic level
therapeutic levelDA: 29 PA: 98 MOZ Rank: 82
Link: https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7467252/
Description: WebSep 2, 2020 · Total VPA serum concentration, when measured clinically, has a recommended therapeutic range of 50–100 mcg/mL . However, VPA is highly bound to albumin, and the binding capacity becomes saturated when the serum concentration increases, resulting in higher amounts of free (unbound) VPA [ 5 ].
DA: 30 PA: 43 MOZ Rank: 80
Link: https://www.medicalnewstoday.com/articles/drugs-depakote
Description: WebDec 7, 2023 · Birth control needs. Breastfeeding. Depakote and Depakote ER and alcohol. Interactions. How to take. How they work. Precautions. Overdose. Expiration. Depakote and Depakote ER are...
DA: 78 PA: 20 MOZ Rank: 32
Link: https://cdn.mdedge.com/files/s3fs-public/cp01604e1.pdf
Description: WebTable 1. Relationship between free valproic acid fraction (α) and serum albumin concentration. that are responsible for its therapeutic effect.2 Monitoring total VPA levels in patients with hypoalbuminemia could reveal seemingly subtherapeutic VPA lev-els, which could lead to unnecessary dos-age adjustments or drug toxicity.
DA: 4 PA: 57 MOZ Rank: 39
Link: https://www.drugs.com/pro/depakote.html
Description: WebGeneric name: divalproex sodium. Dosage form: tablet, delayed release. Drug class: Fatty acid derivative anticonvulsants. Medically reviewed by Drugs.com. Last updated on Sep 27, 2023. On This Page. Indications and Usage. Dosage and Administration. Dosage Forms and Strengths. Contraindications. Warnings and Precautions.
DA: 14 PA: 90 MOZ Rank: 52
Link: https://www.ncbi.nlm.nih.gov/books/NBK560898/
Description: WebNov 27, 2022 · Toxicity can occur with dose adjustments to reach the therapeutic level, in patients with metabolic derangements, with drug-drug interactions, or in attempts to cause self-harm.
DA: 56 PA: 62 MOZ Rank: 55
Link: https://clinlab.ucsf.edu/sites/g/files/tkssra1861/f/wysiwyg/Drug_level_monitoring_card.pdf
Description: WebValproic Acid (Depakote®, Depakene®) Within 30 minutes before dose 2-3 DAYS 50-125 mg/L Vancomycin Within 30 minutes before 4th dose 3 doses 10-20 mg/L 15-20 mg/L for serious infections Pre or Post Hemodialysis (HD) Aminoglycosides: Gentamicin or Tobramycin Pre HD or 1 hour Post HD level before a dose to determine if redosing needed
DA: 23 PA: 35 MOZ Rank: 82
