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  • 1. Poly (ADP-ribose) polymerase - Wikipedia

    wikipedia.org

    Link: https://en.m.wikipedia.org/wiki/Poly_(ADP-ribose)_polymerase

    Description: WEBPoly (ADP-ribose) polymerase ( PARP) is a family of proteins involved in a number of cellular processes such as DNA repair, genomic stability, and programmed cell death. [1] Members of PARP family. The PARP family comprises 17 members (10 putative). [2] . They vary greatly in structure and function within the cell.

    DA: 22 PA: 26 MOZ Rank: 83

  • 2. Review of Poly (ADP-ribose) Polymerase (PARP) Mechanisms of Action …

    nih.gov

    Link: https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4806654/

    Description: WEBPARP is a critical enzyme involved in DNA repair and many other cellular processes including transcription and modulation of chromatin structure. PARP plays a central role in NER and BER, and enables repair of DNA damage caused by alkylating agents and chemotherapeutic drugs.

    DA: 92 PA: 81 MOZ Rank: 14

  • 3. What are PARP inhibitors? | MD Anderson Cancer Center

    mdanderson.org

    Link: https://www.mdanderson.org/cancerwise/what-are-parp-inhibitors.h00-159696756.html

    Description: WEBApril 03, 2024. What are PARP inhibitors? BY Erin Dahlstrom, Ph.D. PARP inhibitors are a type of targeted therapy commonly used to treat breast cancer and ovarian cancer, among others. They target PARP, or poly (ADP-ribose) polymerase, which is a protein in cells that helps repair damaged DNA.

    DA: 4 PA: 91 MOZ Rank: 27

  • 4. What is a PARP inhibitor? Uses, how they work, and options

    medicalnewstoday.com

    Link: https://www.medicalnewstoday.com/articles/parp-inhibitor

    Description: WEBMar 15, 2021 · Summary. PARP inhibitors are a type of cancer drug. PARP stands for poly adenosine diphosphate-ribose polymerase, a type of enzyme that helps repair DNA damage in cells. PARP inhibitors work by...

    DA: 6 PA: 6 MOZ Rank: 14

  • 5. PARP inhibitor - Wikipedia

    wikipedia.org

    Link: https://en.m.wikipedia.org/wiki/PARP_inhibitor

    Description: WEBPARP inhibitors are a group of pharmacological inhibitors of the enzyme poly ADP ribose polymerase (PARP). They are developed for multiple indications, including the treatment of heritable cancers. [1] . Several forms of cancer are more dependent on PARP than regular cells, making PARP ( PARP1, PARP2 etc) …

    DA: 81 PA: 41 MOZ Rank: 39

  • 6. PARP Inhibitors: Clinical Relevance, Mechanisms of Action and …

    nih.gov

    Link: https://pubmed.ncbi.nlm.nih.gov/33015058/

    Description: WEBSep 9, 2020 · PARP inhibitors (PARPi) were the first approved cancer drugs that specifically targeted the DNA damage response in BRCA1/2 mutated breast and ovarian cancers. Since then, there has been significant advances in our understanding of the mechanisms behind sensitization of tumors to PARP inhibitors and expansion of …

    DA: 83 PA: 39 MOZ Rank: 67

  • 7. The multifaceted roles of PARP1 in DNA repair and chromatin

    nature.com

    Link: https://www.nature.com/articles/nrm.2017.53

    Description: WEBJul 5, 2017 · PARP1 post-translationally modifies itself and a range of other proteins that have diverse roles in different cellular processes. The catalytic activity of PARP1 is responsible for mediating...

    DA: 17 PA: 65 MOZ Rank: 59

  • 8. Poly (ADP-ribose) polymerase inhibition: past, present and future

    nature.com

    Link: https://www.nature.com/articles/s41573-020-0076-6

    Description: WEBSep 3, 2020 · The nuclear enzyme poly (ADP-ribose) polymerase 1 (PARP1) was first described more than 50 years ago 1, 2, 3 and is now known to play important roles in DNA repair and the maintenance...

    DA: 33 PA: 89 MOZ Rank: 2

  • 9. PARP Power: A Structural Perspective on PARP1, PARP2, and …

    nih.gov

    Link: https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8150716/

    Description: WEBMay 12, 2021 · Poly ADP-ribose polymerase (PARP) enzymes play a key role in a number of cellular processes, such as DNA repair, genome maintenance, and cell death [ 1, 2, 3, 4, 5, 6, 7 ]. The best characterised member of the PARP family is PARP1, which was first identified for its role in the recognition and repair of single-strand DNA breaks (SSB) [ 8, 9 ].

    DA: 81 PA: 47 MOZ Rank: 7

  • 10. Mechanism and current progress of Poly ADP-ribose polymerase (PARP

    sciencedirect.com

    Link: https://www.sciencedirect.com/science/article/pii/S0753332219352837

    Description: WEBMar 1, 2020 · The multi-functional enzyme Poly ADP ribose polymerase (PARP) plays an impart role in DNA damage repair and genome stability. PARP inhibitors inhibit DNA repair pathways and cause apoptosis of cancer cells, especially in homologous recombination (HR)-deficient cells.

    DA: 29 PA: 37 MOZ Rank: 93