Link: https://en.wikipedia.org/wiki/PDX1
Description: WEBPDX1 (pancreatic and duodenal homeobox 1), also known as insulin promoter factor 1, is a transcription factor in the ParaHox gene cluster. In vertebrates, Pdx1 is necessary for pancreatic development, including β-cell maturation, and duodenal differentiation.
DA: 20 PA: 54 MOZ Rank: 24
Link: https://www.ncbi.nlm.nih.gov/gene/3651
Description: WEBApr 13, 2024 · Pdx1 is a transcription factor required for the formation of endocrine pancreas that is inhibited during Coxsackievirus B4 infection of human pancreas ductal cells; recessive PDX1 mutations are a rare but important cause of isolated permanent neonatal diabetes in patients without pancreatic hypoplasia/agenesis
DA: 75 PA: 46 MOZ Rank: 93
Link: https://www.genecards.org/cgi-bin/carddisp.pl?gene=PDX1
Description: WEBApr 3, 2024 · PDX1 (Pancreatic And Duodenal Homeobox 1) is a Protein Coding gene. Diseases associated with PDX1 include Maturity-Onset Diabetes Of The Young, Type 4 and Pancreatic Agenesis 1. Among its related pathways are Regulation of beta-cell development and Nervous system development.
DA: 43 PA: 25 MOZ Rank: 19
Link: https://www.frontiersin.org/articles/10.3389/fmolb.2022.1091757/full
Description: WEBDec 1, 2022 · Understanding the role of key players in the pathogenesis of diabetes and the related β-cell functions is of great importance in combating diabetes. PDX1 is a master regulator in pancreas organogenesis, the maturation and identity preservation of β-cells, and of their role in normal insulin function.
DA: 86 PA: 58 MOZ Rank: 26
Link: https://www.nature.com/articles/s41467-020-20632-z
Description: WEBJan 29, 2021 · Nature Communications - Beta cell subpopulations with low expression in PDX1, MAFA, and insulin might contribute to islet function and insulin release. Here the authors show that altering the...
DA: 83 PA: 3 MOZ Rank: 17
Link: https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2802270/
Description: WEBPancreatic duodenal homeobox 1 (Pdx1) is a transcription factor that plays a central role in pancreatic β-cell function and survival. Complete deficiency of Pdx1 is associated with pancreatic agenesis and partial deficiency leads to severe β-cell dysfunction, and increases β-cell death and diabetes both in rodent and human. Chronic ...
DA: 95 PA: 46 MOZ Rank: 90
Link: https://www.jbc.org/article/S0021-9258(22)01066-3/fulltext
Description: WEBOct 19, 2022 · PDX1 in development and glucose homeostasis. The pancreatic and duodenal homeobox 1 (PDX1) (also known as GSF ( 1. ), IDX-1 ( 2. ), IPF1 ( 3. ), IUF ( 4. ), and STF-1 ( 5. )) is the central activator of glucose-dependent insulin transcription in pancreatic β cells ( 4. ).
DA: 1 PA: 21 MOZ Rank: 41
Link: https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9775243/
Description: WEBNov 30, 2022 · The pancreatic duodenum homeobox-1 ( PDX-1) is a transcription factor encoded by a Hox-like homeodomain gene that plays a crucial role in pancreatic development, β-cell differentiation, and the maintenance of mature β-cell functions.
DA: 53 PA: 24 MOZ Rank: 14
Link: https://pubmed.ncbi.nlm.nih.gov/25845046/
Description: WEBThe homeodomain-containing transcription factor pancreatic duodenal homeobox 1 (PDX-1) plays a key role in pancreatic development and β-cell function. It is a major regulator of transcription in pancreatic cells, and transactivates the insulin gene by binding to a specific DNA motif in its promoter …
DA: 48 PA: 38 MOZ Rank: 87
Link: https://pubmed.ncbi.nlm.nih.gov/36551213/
Description: WEBNov 30, 2022 · The pancreatic duodenum homeobox-1 ( PDX-1) is a transcription factor encoded by a Hox-like homeodomain gene that plays a crucial role in pancreatic development, β-cell differentiation, and the maintenance of mature β-cell functions.
DA: 44 PA: 4 MOZ Rank: 15
